abstract：:The analysis of the lytic mechanism initiated by TNFalpha in three human ovarian cell lines (CAOV-3, SK-OV-3, and OVCAR-3) and in three human cervical cell lines (SIHa, HT-3, and ME-180) in the presence of inhibitors of protein synthesis indicates that this lytic mechanism is similar to the protein synthesis-independe...

journal_title：Gynecologic oncology

authors： Powell CB,Scott JH,Collins JL

更新日期：1996-07-01 00:00:00

abstract：:The usefulness of percutaneous endoscopic gastrostomy (PEG) for decompression in patients with unresolving intestinal obstruction by gynecological malignancy is examined. Between April 1993 and August 1995, 34 consecutive patients with small-bowel obstruction by gynecological cancer, heavily pretreated with surgery an...

journal_title：Gynecologic oncology

authors： Campagnutta E,Cannizzaro R,Gallo A,Zarrelli A,Valentini M,De Cicco M,Scarabelli C

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:The friable and hypervascular nature of a metastatic invasive mole places the patient at risk for significant hemorrhage. Bleeding is the chief cause of morbidity and mortality in patients with a histopathological diagnosis of invasive mole. Bleeding from vaginal metastatic lesions can be controlled by packi...

journal_title：Gynecologic oncology

authors： Method MW,Hirschfield M,Everette HE

更新日期：1996-06-01 00:00:00

abstract：:The purpose of this study was to determine the response of vulvar intraepithelial neoplasia (VIN) lesions to standard treatment methods in women infected with human immunodeficiency virus (HIV). We reviewed all cases of VIN over a 4-year period at an inner-city hospital. We reviewed the clinical records of these women...

journal_title：Gynecologic oncology

authors： Korn AP,Abercrombie PD,Foster A

更新日期：1996-06-01 00:00:00

abstract：:In situ hybridization (ISH) and polymerase chain reaction (PCR) for several common HPV types were performed on 41 cases of vulvar dystrophy, 19 of which were associated with previous or simultaneous invasive squamous cell carcinoma of the vulva. Three of the 19 cases (16%) of dystrophy associated with cancer were foun...

journal_title：Gynecologic oncology

authors： Sagerman PM,Choi YJ,Hu Y,Niedt GW

更新日期：1996-06-01 00:00:00

abstract：:A case of high-grade endometrioid adenosquamous carcinoma of the ovary showing pilomatricoma-like areas and neuroendocrine differentiation is presented. The pilomatricoma-like areas were strongly positive for cytokeratin and vimentin, whereas the poorly differentiated areas of the tumor were positive for cytokeratin, ...

journal_title：Gynecologic oncology

authors： Fang J,Keh P,Katz L,Rao MS

更新日期：1996-05-01 00:00:00

abstract：:This study was designed to compare the effectiveness of loop excision procedures as ablation and conization equivalents, and their use in recurrent cervical high-grade dysplasia patients. We retrospectively reviewed patients undergoing loop procedures between January 1992 and April 1994. Conization equivalents were de...

journal_title：Gynecologic oncology

authors： Gold M,Dunton CJ,Murray J,Macones G,Hanau C,Carlson JA Jr

更新日期：1996-05-01 00:00:00

abstract：:To develop a mapping strategy for improved detection of p53 allelic loss associated with ovarian carcinoma, we utilized multiple intragenic polymorphisms and single-strand conformation polymorphism (SSCP) analysis. p53 allelotype distributions were defined for 80 ovarian cancer patients from germ-line DNA. All polymor...

journal_title：Gynecologic oncology

authors： Skilling JS,Powills K,Lager DJ,Anderson B,Sorosky J,Buller RE

更新日期：1996-05-01 00:00:00

abstract：:The aim of the present study was to compare the diagnostic accuracy of transvaginal sonography, color flow imaging, and serum CA 125 assay in pre- and postmenopausal women undergoing laparotomy for a clinical diagnosis of an adnexal mass. In 109 consecutive women, the morphology of the mass was evaluated with transvag...

journal_title：Gynecologic oncology

authors： Strigini FA,Gadducci A,Del Bravo B,Ferdeghini M,Genazzani AR

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVE:The aim of our study was to retrospectively examine the proliferating cell nuclear antigen (PCNA) immunoreactivity of tumor cells in curettage specimens containing endometrioid adenocarcinoma and obtained immediately before definitive surgical staging. This PCNA index was compared with the one subsequently de...

journal_title：Gynecologic oncology

authors： Garzetti GG,Ciavattini A,Goteri G,De Nictolis M,Romanini C

更新日期：1996-04-01 00:00:00

abstract：:Two patients with resistant gestational choriocarcinoma were treated w with Taxol after extensive prior chemotherapy including EMACO and platinum-based salvage chemotherapy. Both patients showed significant responses to Taxol. One patient relapsed in the brain and liver after treatment and died. Taxol was combined wit...

journal_title：Gynecologic oncology

authors： Jones WB,Schneider J,Shapiro F,Lewis JL Jr

更新日期：1996-04-01 00:00:00

abstract：:HIV infection among women is increasing in the United States. Since January 1993, cervical cancer has been considered an AIDS-defining illness. We report a rare case of squamous cell carcinoma arising in a teratoma of the uterine cervix in an HIV-infected patient. This patient was treated with a radical hysterectomy, ...

journal_title：Gynecologic oncology

authors： Bell MC,Schmidt-Grimminger DC,Connor MG,Alvarez RD

更新日期：1996-03-01 00:00:00

abstract：:The presence of oncogenic HPV DNAs (HPV-16/18) in cervical carcinomas and their normal and metastatic pelvic lymph nodes and the expression patterns of proliferating cell nuclear antigen (PCNA) in cervical carcinomas were retrospectively studied to elucidate the possible roles of them in malignant transformation and p...

journal_title：Gynecologic oncology

authors： Park JS,Rhyu KS,Kim CJ,Kim HS,Han KT,Ahn HK,Kim SJ,Namkoong SE

更新日期：1996-03-01 00:00:00

abstract：OBJECTIVES:The role of the candidate metastasis-suppressor gene nm23-H1 first characterized in breast cancer remains controversial, with both metastasis suppression and disease progression being linked to elevated nm23-H1 gene expression in different human tumor types. We sought to characterize (1) the pattern and inte...

journal_title：Gynecologic oncology

authors： Srivatsa PJ,Cliby WA,Keeney GL,Dodson MK,Suman VJ,Roche PC,Podratz KC

更新日期：1996-03-01 00:00:00

abstract：:Only one case of endometrial transitional cell carcinoma (TCC) has been previously reported in the literature. We report a second case. In both the previously reported case and in this case there was a separate focus of TCC in the adnexa. Both patients were treated with adjuvant whole pelvic radiation and are alive an...

journal_title：Gynecologic oncology

authors： Spiegel GW,Austin RM,Gelven PL

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVE:In the present study we detected 72-kDa metalloproteinase expression in our series of early stage cervical carcinomas and analyzed the relationship between 72-kDa metalloproteinase staining and risk of nodal involvement with the goal of identifying a parameter useful in predicting the metastatic potential of ...

journal_title：Gynecologic oncology

authors： Garzetti GG,Ciavattini A,Lucarini G,Goteri G,Romanini C,Biagini G

更新日期：1996-02-01 00:00:00

abstract：:In an attempt to evaluate the stability of DNA content in ovarian carcinoma, 66 tumor specimens from 25 patients with stage III disease were analyzed by flow cytometry. For all patients, both primary tumor and omental metastasis were available, and for 16 patients the persistent tumor found at second-look operation wa...

journal_title：Gynecologic oncology

authors： Zanetta GM,Keeney GL,Kimlinger TK,Katzmann JA,Podratz KC

更新日期：1996-02-01 00:00:00

abstract：:Forty patients with locally advanced cervical carcinoma were entered into a protocol utilizing the bolus administration of both mitomycin C (10 or 15 mg) on Day 1 and 5-fluorouracil (400 mg) on Day 1-5 followed by sequential pelvic irradiation on Day 6 between September 1980 and October 1985. All patients had poor-pro...

journal_title：Gynecologic oncology

authors： Denehy TR,Eastman R,SanFilippo L,Gregori CA,Breen JL

更新日期：1996-01-01 00:00:00

abstract：:Between 1965 and 1988, 125 patients with primary invasive vaginal carcinoma were treated with radiation therapy at the Center of Oncology in Kraków. Twenty-two superficial stage I patients received radium or cesium intracavitary radiation alone. The remaining 11 patients with stage I disease whose lesions were either ...

journal_title：Gynecologic oncology

authors： Urbański K,Kojs Z,Reinfuss M,Fabisiak W

更新日期：1996-01-01 00:00:00

abstract：:Between 1975 and 1989, 896 patients were treated for endometrial carcinoma at the Massachusetts General Hospital. Thirty patients were identified from the tumor registry as having uterine papillary serous carcinomas. The survival for all patients and for groups of patients stratified on clinical and pathological param...

journal_title：Gynecologic oncology

authors： Kato DT,Ferry JA,Goodman A,Sullinger J,Scully RE,Goff BA,Fuller AF Jr,Rice LW

更新日期：1995-12-01 00:00:00

abstract：:Leiomyosarcoma, a rare malignancy of smooth muscle, may arise from the retroperitoneum and present with the same vague symptoms as a malignancy of the pelvic organs. The purpose of this paper is to review eight cases of retroperitoneal leiomyosarcoma and to illustrate the presenting symptoms, prognostic indicators, an...

journal_title：Gynecologic oncology

authors： Todd CS,Michael H,Sutton G

更新日期：1995-12-01 00:00:00

abstract：:Episiotomy scar tumor implantation arising from a cervical carcinoma is rare. This report details a patient who developed an episiotomy implant from a "microinvasive" adenocarcinoma of the cervix 5 months following vaginal delivery. The implant behaved as a primary focus for metastases to the inguinal lymph nodes. Des...

journal_title：Gynecologic oncology

authors： Van den Broek NR,Lopes AD,Ansink A,Monaghan JM

更新日期：1995-11-01 00:00:00

abstract：:Fifty consecutive patients with documented advanced or recurrent endometrial carcinoma from 1978 through 1985 were prospectively treated with melphalan, 5-fluorouracil, medroxyprogesterone acetate (MFP) as first-line chemotherapy. From 1987 through 1993, 50 consecutive patients with documented advanced or recurrent en...

journal_title：Gynecologic oncology

authors： Cornelison TL,Baker TR,Piver MS,Driscoll DL

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:To assess the relationship between low-dose tamoxifen, usage and endometrial cancer in breast cancer patients. METHODS:In this case-control study, the records of the 1017 patients treated at Wilford Hall Medical Center for primary breast cancer between 1978 and 1989 were reviewed. Dose and duration of tamoxi...

journal_title：Gynecologic oncology

authors： Robinson DC,Bloss JD,Schiano MA

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:Overexpression of the tyrosine kinase receptor erbB-2 is important in the pathogenesis of a variety of neoplasms including ovarian cancer. As a strategy to selectively eradicate erbB-2-overexpressing tumor cells, an anti-erbB-2 single-chain immunoglobin (sFv) gene was constructed to direct expression of intra...

journal_title：Gynecologic oncology

authors： Deshane J,Cabrera G,Grim JE,Siegal GP,Pike J,Alvarez RD,Curiel DT

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVE:To examine the effect of postsurgical surveillance on survival of patients with FIGO stage I/II endometrial adenocarcinoma. METHODS:We examined the records of 354 patients who underwent primary surgical therapy for FIGO stage I/II endometrial adenocarcinoma. In patients who developed recurrent disease, we de...

journal_title：Gynecologic oncology

authors： Berchuck A,Anspach C,Evans AC,Soper JT,Rodriguez GC,Dodge R,Robboy S,Clarke-Pearson DL

更新日期：1995-10-01 00:00:00

abstract：:The accuracy of preconization cytology and histology was evaluated in 536 patients undergoing combination laser conization. Exact agreement between cytology and cone diagnosis was observed in 41.8% of the patients. The lowest agreement, 13.6% was demonstrated in cytologic cervical intraepithelial neoplasia (CIN) I, th...

journal_title：Gynecologic oncology

authors： Andersen ES,Nielsen K,Pedersen B

更新日期：1995-10-01 00:00:00

abstract：:Most rhabdomyosarcomas (RMSs) of the female genital tract occur in infants and young children as sarcoma botryoides. Vaginal RMS occurring in a postmenopausal woman is extremely rare. To our knowledge, only three vaginal RMSs have been reported in patients who were over 50 years of age. Herein, the first case in Taiwa...

journal_title：Gynecologic oncology

authors： Shy SW,Lee WH,Chen D,Ho SY

更新日期：1995-09-01 00:00:00

abstract：PURPOSE:The primary goal of this trial was to evaluate the clinical activity and the toxicity of a combination of cisplatin and carboplatin for women with advanced-stage epithelial ovarian cancer. PATIENTS AND METHODS:Fifty-one consecutive evaluable patients with untreated stage III and IV epithelial ovarian cancer re...

journal_title：Gynecologic oncology

authors： Gershenson DM,Morris M,Burke TW,Levenback C,Kavanagh JJ,Fromm GL,Silva EG,Warner D,Wharton JT

更新日期：1995-09-01 00:00:00

abstract：:Adenocarcinoma in situ (AIS) of the cervix is a controversial entity which is being encountered with increasing frequency. Current critical issues in its management are the safety of uterine preservation in younger patients and the use of LLETZ conization. A 28-year-old patient was diagnosed with AIS and managed with ...

journal_title：Gynecologic oncology

authors： Kennedy AW,elTabbakh GH,Biscotti CV,Wirth S

更新日期：1995-08-01 00:00:00

abstract：:Human ovarian carcinoma cell lines were genetically engineered to secrete the cytokine interleukin-4 (IL-4) by retroviral-mediated gene transduction. These cells were transduced with the LXSN retroviral vector containing the human IL-4 gene and the neomycin resistance selection marker. Numerous IL-4-secreting clones w...

journal_title：Gynecologic oncology

authors： Santin AD,Ioli GR,Hiserodt JC,Rose GS,Graf MR,Tocco LM,Lander JK,Eck LM,Burger RA,DiSaia PJ

更新日期：1995-08-01 00:00:00

abstract：:A review of several professional service agreements (PSA) of managed care organizations which contract with gynecologic oncologists in the Southern California area demonstrates several distinct patterns of practice restrictions and financial benefits which can help guide the physician who is considering signing such a...

journal_title：Gynecologic oncology

authors： Berman ML

更新日期：1995-08-01 00:00:00

abstract：:To test the association between cytotoxicity and in vitro cell cycle perturbations we systematically studied cell cycle perturbations after exposing human ovarian cancer cells to nine commonly used cytotoxic agents. Three principal patterns of cell cycle alterations were observed: a sequential S-G2/M block after expos...

journal_title：Gynecologic oncology

authors： Petru E,Sevin BU,Haas J,Ramos R,Perras J

更新日期：1995-07-01 00:00:00

abstract：:Primary adenocarcinoma of the jejunum which accounts for only approximately 3% of all gastrointestinal tract malignancies, is distinctly unusual. Ovarian metastasis from a jejunal cancer is extremely rare. It has significant therapeutic and prognostic implications to differentiate primary ovarian carcinoma from metast...

journal_title：Gynecologic oncology

authors： Tsuruchi N,Kubota H,Tsukamoto N,Kurano A

更新日期：1995-07-01 00:00:00

abstract：:A case of Stage IV endometrial squamous cell carcinoma occurring 8 years after a low anterior resection and whole pelvic radiation therapy for a Dukes D colon carcinoma is presented. Koilocytosis was present in the tumor. There was no evidence of human papillomavirus antigen or DNA in the tumor. The patient was treate...

journal_title：Gynecologic oncology

authors： Sorosky JI,Kaminski PF,Kreider J,Podczaski ES,Olt GJ,Zaino R

更新日期：1995-06-01 00:00:00

abstract：:The altered expression of histocompatibility leukocyte antigens (HLA) in the development to cervical carcinoma suggests that tumor progression may be related to impaired recognition by host immune defense mechanisms. To investigate whether this phenomenon plays a role in the process of metastasis of cervical cancer, w...

journal_title：Gynecologic oncology

authors： Hilders CG,Munoz IM,Nooyen Y,Fleuren GJ

更新日期：1995-06-01 00:00:00

abstract：:Despite high initial response rates to platinum-based chemotherapy, most patients with advanced ovarian carcinoma die of drug-resistant disease. Drug resistance can be overcome in the hematologic malignancies and lymphomas with high-dose therapy and bone marrow transplantation (BMT) when used early, suggesting that th...

journal_title：Gynecologic oncology

authors： Stiff P,Bayer R,Camarda M,Tan S,Dolan J,Potkul R,Loutfi S,Kinch L,Sosman J,Peace D

更新日期：1995-06-01 00:00:00

abstract：:Over a 7-year period from 1987 to 1994, 120 patients consecutive patients with FIGO stage IB invasive cervical cancer who underwent type 3 radical abdominal hysterectomy and bilateral pelvic lymphadenectomy had either Jackson-Pratt closed-suction drainage (Group 1, patients 1-60) or no drainage (Group 2, patients 61-1...

journal_title：Gynecologic oncology

authors： Patsner B

更新日期：1995-05-01 00:00:00

abstract：:A retrospective analysis of 45 patients with epithelial ovarian carcinoma who underwent second-look procedure after initial cytoreduction and platinum-based combination chemotherapy was undertaken. Each patient was evaluated for the result of CA 125 after a third course of chemotherapy, the result of CA 125 prior to s...

journal_title：Gynecologic oncology

authors： Folk JJ,Botsford M,Musa AG

更新日期：1995-05-01 00:00:00

abstract：:A new cell line, CUMC-3, has been derived from an invasive nonkeratinizing squamous cell carcinoma of the uterine cervix in a 32-year-old patient. It has been maintained in long-term culture for 59 months, and passaged over 310 times. Monolayer-cultured cells were polygonal in shape, showing a pavement-like arrangemen...

journal_title：Gynecologic oncology

authors： Kim JW,Cho YH,Lyu MS,Lee CG,Jung JK,Kim SJ,Namkoong SE

更新日期：1995-04-01 00:00:00